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KMID : 1007520180270061791
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Food Science and Biotechnology
2018 Volume.27 No. 6 p.1791 ~ p.1799
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Oligopeptide derived from solid-state fermented cottonseed meal significantly affect the immunomodulatory in BALB/c mice treated with cyclophosphamide
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Liu Jiancheng
Sun Hong
Nie Cunxi
Ge Wenxia
Wang Yongqiang
Zhang Wenju
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Abstract
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In this study, the immunomodulatory activity of oligopeptide (CP) derived from solid-state fermented cottonseed meal were investigated in immunosuppressed BALB/c mice models by treatment with cyclophosphamide (CY). Results indicated that oligopeptide increased the thymus and spleen indices of CY-treated mice. The count of plague forming cells (PFC) and the content of half serum hemolysis (HC50) in immunosuppressive mice were restored to the normal level in CP-10 and CP-20 groups while the cytokines interleukin (IL)-2, IL-6, and tumor necrosis factor alpha (TNF-α) were increased significantly in CP-20 group. Similar increasing the immunoglobulin of IgG and IgM content in the serum of CP-10 group were also observed. These findings indicated that oligopeptide derived from solid-state fermented cottonseed meal had a strong immune-enhancing activity as well as a protective effect against immunosuppression induced by cyclophosphamide in mice.
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KEYWORD
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Cottonseed meal, Solid-state fermentation, Oligopeptide, Cyclophosphamide, Immunomodulatory
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